D-cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-D-aspartate receptor-ionophore complex in Alzheimer brain
IP Chessell, AW Procter, PT Francis, DM Bowen - Brain research, 1991 - Elsevier
The action of d-Cycloserine (DCS) at the strychnine-insensitive glycine recognition site of
the NMDA receptor-ionophore complex has been studied with membranes from inferior
parietal cortex of patients with Alzheimer's disease. The maximal response of the site,
measured using [3 H] MK-801 binding, was 64% of that observed with glycine. Stimulation of
binding induced by DCS in the presence of fixed concentrations of glycine resulted in a
family of dose-response curves, consistent with the antibiotic having the property of a partial …
the NMDA receptor-ionophore complex has been studied with membranes from inferior
parietal cortex of patients with Alzheimer's disease. The maximal response of the site,
measured using [3 H] MK-801 binding, was 64% of that observed with glycine. Stimulation of
binding induced by DCS in the presence of fixed concentrations of glycine resulted in a
family of dose-response curves, consistent with the antibiotic having the property of a partial …
以上显示的是最相近的搜索结果。 查看全部搜索结果